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Mitosis

Mitosis is the process by which cells accurately separate their duplicated genome into the two new daughter cells. The chromosomes condense as cells enter mitosis and special structures referred to as kinetochores are established on the centromere region. The kinetochores are able to stably bind to the dynamic microtubules of the mitotic spindle which at anaphase allows the segregation of sister chromatids.  To ensure that the genome is segregated equally to the two new daughter cells the spindle assembly checkpoint (SAC) delays mitotic progression until all chromosomes have properly bioriented on the mitotic spindle, ensuring genomic integrity. This checkpoint is the target of the cancer therapy compounds such as taxanes and vinca alkaloids. Commonly referred to as antimitotics, these drugs disrupt the formation of a functional mitotic spindle, thereby inducing a prolonged mitotic arrest through the activation of the SAC.

 

This video illustrates the fundamentals of mitosis

 

News

 

 

July 2016

Our PP2A-B56 motif paper

online in Molecular Cell

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July 2016

Our two pool BubR1 paper now

online at Nature Communications

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March 2016

Our Cdc20 phosphorylation paper

is now online at

Nature Communications

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